Concept:Use the laws of indices to simplify powers with the same base before multiplying.Explanation:Write each number as a power of its prime base.81=34, 25=52, and 243=35.Apply the power law: (am)n=amn.81−43=(34)−43=3−3=271.2521=(52)21=51=5.24352=(35)52=32=9.Now combine the simplified values.271×5×9=2745.Reduce the fraction: 2745=35.Answer:D. 35